Born in 1987 in Tashkent, Uzbek Soviet Socialist Republic. She was a student of Anatoly Osmolovsky, a graduate of the Institute of Contemporary Art in Moscow. From 2017 to 2018, she was a scholarship recipient of the Joseph Brodsky Scholarship Foundation and a resident of the American Academy in Rome. In 2015, Forbes magazine named Alisa one of the most promising young artists in Russia. In 2014, she created the cover for the vinyl Three Songs for Margherita Cagol by the punk band Frazione Brigate Rosse. From 2017 to 2020, she collaborated with brands Cartier, Comme des Garçons, Maison Margiela and Bonne Suits. In 2019, the book Moscow Light by Igor Mukhin was published with Alisa's painting on the cover. In 2020, Art Newspaper Russia ranked Alisa 4th in the ranking of the 50 most promising Russian artists. She is also among the leading young artists of Russia according to experts from the Afisha Daily website.

In 2021, she received the Demyan Bedny Prize in the Left Perspective category. Her solo exhibitions have been held in Russia, Germany, the Netherlands and Sweden. She took part in the First Triennial of Russian Contemporary Art, the Third Ural Biennale, the parallel program of the 55th Venice Biennale, as well as the Third and Fifth Moscow Biennales of Contemporary Art. Alisa Yoffe's works are in the Tretyakov Gallery (Russia), VAC Foundation (Russia), Stella Art Foundation (Russia), Vladimir Smirnov and Konstantin Sorokin Foundation (Russia), PERMM Museum of Contemporary Art (Russia), Klaipeda Cultural Communication Center (Lithuania), Horvath Art Foundation (Hungary), Phoenix Art Museum of Contemporary Art (USA) and others. She currently lives and works in Paris.